Funding sources: None
Maternal obesity and Down syndrome in the offspring: is there a link?
Article first published online: 3 APR 2014
© 2014 John Wiley & Sons, Ltd.
Volume 34, Issue 4, pages 307–309, April 2014
How to Cite
Ghidini, A. (2014), Maternal obesity and Down syndrome in the offspring: is there a link?. Prenat. Diagn., 34: 307–309. doi: 10.1002/pd.4341
Conflicts of interest: None declared
- Issue published online: 3 APR 2014
- Article first published online: 3 APR 2014
- Manuscript Accepted: 7 FEB 2014
- Manuscript Received: 31 JAN 2014
What's already known about this topic?
- Obesity has several adverse effects on the fetal and neonatal outcomes
- Obesity leads to underdetection of fetal sonographic markers of aneuploidies and of fetal anomalies, as well as underperformance of maternal serum screening test for common aneuploidies
- Obesity can be associated with malnutrition and lower levels of essential vitamins
What does this study add?
- The reported increased risk of offspring with Down syndrome in obese women (corrected for maternal age) could be due to more frequent non-disjunctional events or under-detection of affected fetuses