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What's already known about this topic?

  • Obesity has several adverse effects on the fetal and neonatal outcomes
  • Obesity leads to underdetection of fetal sonographic markers of aneuploidies and of fetal anomalies, as well as underperformance of maternal serum screening test for common aneuploidies
  • Obesity can be associated with malnutrition and lower levels of essential vitamins

What does this study add?

  • The reported increased risk of offspring with Down syndrome in obese women (corrected for maternal age) could be due to more frequent non-disjunctional events or under-detection of affected fetuses