Part of the study has been presented as an oral presentation in the XX FIGO World Congress of Gynecology and Obstetrics.
Role of maternal plasma levels of placental growth factor for the prediction of maternal complications in preeclampsia according to the gestational age at onset†
Article first published online: 8 JUL 2014
© 2014 John Wiley & Sons, Ltd.
Special Issue: Abnormal Placentation and Adverse Obstetric Outcomes: Screening, Diagnosis and Treatment
Volume 34, Issue 7, pages 706–710, July 2014
How to Cite
Meler, E., Scazzocchio, E., Peguero, A., Triunfo, S., Gratacos, E. and Figueras, F. (2014), Role of maternal plasma levels of placental growth factor for the prediction of maternal complications in preeclampsia according to the gestational age at onset. Prenat. Diagn., 34: 706–710. doi: 10.1002/pd.4390
Funding sources: Biochemical measurements of PlGF were sponsored by Alere, San Diego (USA).
Conflicts of interest: None declared
- Issue published online: 8 JUL 2014
- Article first published online: 8 JUL 2014
- Accepted manuscript online: 21 APR 2014 06:17PM EST
- Manuscript Accepted: 15 APR 2014
- Manuscript Revised: 14 APR 2014
- Manuscript Received: 13 JAN 2014
This study aimed to describe the distribution of placental growth factor (PlGF) plasma levels in pregnancies complicated by preeclampsia (PE) according to the gestational age at clinical onset and to assess PlGF's predictive role for maternal complications.
A total of 84 women whose pregnancies were complicated by PE before 37 weeks' gestation were enrolled. According to gestational age at onset, three groups were defined: group I, <28 weeks; group II, 28 to 31+6 weeks; and group III, 32 to 36+6 weeks. PlGF plasma levels were measured at diagnosis, and their association with maternal complications was investigated. Plasma PlGF levels below 12 pg/mL were designated as very low.
PlGF levels were very low in seven (87.5%) of eight women diagnosed before 28 weeks' gestation, 29 (78.4%) of 37 patients diagnosed between 28 and 32 weeks' gestation, and 16 (41%) of 39 cases diagnosed after 32 weeks' gestation. The sensitivity of very low PlGF values for predicting maternal complications was 76.9%, but the false positive rate was 65.5%. Positive and negative predictive values were 34.5% and 76.9%, respectively.
The predictive role of a low PlGF level in predicting maternal complications in very early PE is limited because of both its low specificity and low positive predictive value. © 2014 John Wiley & Sons, Ltd.