Funding sources: None
Predictive value of cardiovascular parameters in stages 1 and 2 of twin-to-twin transfusion syndrome
Article first published online: 15 MAY 2014
© 2014 John Wiley & Sons, Ltd.
Volume 34, Issue 9, pages 908–914, September 2014
How to Cite
2014), Predictive value of cardiovascular parameters in stages 1 and 2 of twin-to-twin transfusion syndrome, Prenat Diagn, 34: 908–914. DOI: 10.1002/pd.4393, , , , , , , , , , and (
Conflicts of interest: None declared
- Issue published online: 2 SEP 2014
- Article first published online: 15 MAY 2014
- Accepted manuscript online: 24 APR 2014 01:20AM EST
- Manuscript Accepted: 20 APR 2014
- Manuscript Revised: 31 MAR 2014
- Manuscript Received: 31 JUL 2013
The Quintero staging of twin-to-twin transfusion syndrome (TTTS) does not include a comprehensive cardiovascular assessment. The aim of this study is to assess the predictive value of the myocardial performance index (MPI) and the Children's Hospital of Philadelphia (CHOP) score on recipient survival in Quintero stages 1 and 2 TTTS.
The cohort study was based on prospectively collected data between May 2008 and February 2013 in a population of stages 1 and 2 TTTS. Comparisons between groups were carried out using Student's t-test and χ2-test. A stepwise ascending multivariate logistic regression model was then built.
A total of 73 pregnancies in stages 1 and 2 of Quintero's classification were treated with laser. Rates of recipient fetal losses were higher when MPI was above 0.43 ms (71.4% vs 28.6%, p = 0.022). Rate of CHOP score above 5 was higher in the fetal loss group (28.6% vs 5.1%, p = 0.022). After adjustment for Quintero stages 1 or 2, the risk of recipient loss rate is higher according to CHOP score [OR 7.6; 95% confidence interval (CI) 1.3–43.5] or MPI value (OR 3.7; 95% CI 1.0–13.9).
The CHOP score and MPI are correlated with the recipient survival in stages 1 and 2 TTTS. © 2014 John Wiley & Sons, Ltd.