Presented in part (Abstract 24) at the 17th International Conference on Pharmacoepidemiology, Toronto, Canada, August 23–26, 2001.
Article first published online: 8 NOV 2004
Copyright © 2004 John Wiley & Sons, Ltd.
Pharmacoepidemiology and Drug Safety
Volume 14, Issue 1, pages 53–59, January 2005
How to Cite
Pablos, A. I., Escobar, I., Albiñana, S., Serrano, O., Ferrari, J. M. and de Tejada, A. H. (2005), Evaluation of an antibiotic intravenous to oral sequential therapy program. Pharmacoepidem. Drug Safe., 14: 53–59. doi: 10.1002/pds.1042
No conflict of interest was declared.
- Issue published online: 13 DEC 2004
- Article first published online: 8 NOV 2004
- Manuscript Accepted: 21 SEP 2004
- Manuscript Revised: 13 APR 2003
- Manuscript Received: 18 MAR 2002
- sequential therapy;
This study was designed to analyse the drug consumption difference and economic impact of an antibiotic sequential therapy focused on quinolones.
We studied the consumption of quinolones (ofloxacin/levofloxacin and ciprofloxacin) 6 months before and after the implementation of a sequential therapy program in hospitalised patients. It was calculated for each antibiotic, in its oral and intravenous forms, in defined daily dose (DDD/100 stays per day) and economical terms (drug acquisition cost). At the beginning of the program ofloxacin was replaced by levofloxacin and, since their clinical uses are similar, the consumption of both drugs was compared during the period.
In economic terms, the consumption of intravenous quinolones decreased 60% whereas the consumption of oral quinolones increased 66%. In DDD/100 stays per day, intravenous forms consumption decreased 53% and oral forms consumption increased 36%.
Focusing on quinolones, the implementation of a sequential therapy program based on promoting an early switch from intravenous to oral regimen has proved its capacity to alter the utilisation profile of these antibiotics. The program has permitted the hospital a global saving of $41 420 for these drugs during the period of time considered. Copyright © 2004 John Wiley & Sons, Ltd.