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The third national health and nutrition examination survey (1988–1994)
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Research Article
Prevalence of glucose metabolism abnormalities and cardiovascular co-morbidity in the US elderly adult population†
Article first published online: 23 MAR 2006
DOI: 10.1002/pds.1229
Copyright © 2006 John Wiley & Sons, Ltd.
Additional Information
How to Cite
Varas-Lorenzo, C., Rueda de Castro, A. M., Maguire, A. and Miret, M. (2006), Prevalence of glucose metabolism abnormalities and cardiovascular co-morbidity in the US elderly adult population. Pharmacoepidemiology and Drug Safety, 15: 317–326. doi: 10.1002/pds.1229
- †
Publication History
- Issue published online: 29 APR 2006
- Article first published online: 23 MAR 2006
- Manuscript Accepted: 13 JAN 2006
- Manuscript Revised: 28 OCT 2005
- Manuscript Received: 23 DEC 2004
- Abstract
- References
- Cited By
Keywords:
- diabetes;
- glucose metabolism impairment;
- cardiovascular risk factors;
- elderly
Abstract
Purpose
To estimate the prevalence of glucose metabolism abnormalities, including diabetes, and its associated cardiovascular risk factors and co-morbidity in the US elderly population.
Methods
Cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey (NHANES III, 1988–1994) in adults aged 65 years and more. The 1997 American Diabetes Association (ADA) and the 1998 World Health Organization (WHO) criteria were used to classify the subject's glucose metabolism status. The 2-hour oral glucose tolerance test (OGTT) was performed only among those participants aged 40 to 74 years.
Results
The age-adjusted prevalence of diagnosed diabetes was 12.5% (95% CI: 11.4%–13.6%) among US adults aged 65 years or more. According to the ADA definition 40% of men and 28% of women were affected by some degree of glucose metabolism impairment. According to the WHO definition, 55% of men and 50% of women aged 65 to 74 years were affected by glucose metabolism abnormalities. Mexican-Americans were the most affected under both definitions (51% and 77%, respectively). Overall, 72% of elderly diagnosed diabetics had hypertension, 28% had coronary heart disease (CHD), 47% suffered from cardiovascular disease and 80% of them presented known CHD or multiple coronary risk factors, other than age, level of LDL-cholesterol and diabetes. Under both definitions, a trend towards a worsening coronary risk profile with increased glucose metabolism impairment was observed.
Conclusion
A notable proportion of elderly people is affected by some degree of glucose metabolism impairment which in turn is associated with cardiovascular co-morbidity. Copyright © 2006 John Wiley & Sons, Ltd.