The effect of beta-blocker therapy on quality of life in heart failure patients: a systematic review and meta-analysis

Authors

  • Daniela Dobre MD, MPH,

    Corresponding author
    1. Northern Centre for Health Care Research, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    • Northern Centre for Health Care Research, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
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  • Cornelia H. M. van Jaarsveld PhD,

    1. Northern Centre for Health Care Research, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
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  • Mike J. L. deJongste MD, PhD,

    1. Department of Cardiology, University Medical Centre Groningen, Groningen, The Netherlands
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  • Flora M. Haaijer Ruskamp PhD,

    1. Department of Clinical Pharmacology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
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  • Adelita V. Ranchor PhD

    1. Northern Centre for Health Care Research, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
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  • The study was presented as a poster at the European Society of Cardiology Congress, Munich, Germany, 28 August 2004–1 September 2004.

Abstract

Purpose

To assess the impact of β-blocker therapy on quality of life (QoL) in chronic heart failure (CHF) patients receiving optimal standard medication.

Methods

Randomised controlled trials (RCT) assessing QoL with a generic or disease specific instrument were identified by searching Medline, Embase, Pascual, Cochrane Controlled Trial database, and the bibliographies of the published articles. Studies published between 1985 and 2002 were included, regardless of language of publication. Cochrane Review Manager 4.2 software was used to analyse the data and standardised mean difference (SMD) was calculated to assess the effect on QoL.

Results

A total of 9 trials involving 1954 patients fit into the inclusion criteria for the analysis. QoL improved more in the β-blocker group compared to the control arm, but the SMD did not reach statistical significance (SMD, 0.07; 95%CI [−0.16, 0.02]; p = 0.13). Subgroup analysis, per type of β-blocker and various treatment follow-up showed similar results.

Conclusions

In this meta-analysis there is evidence that β-blocker therapy, on top of standard medication, does not impair QoL. Clinicians may add β-blockers to standard therapy without concerns of impairing QoL in patients with CHF. Copyright © 2006 John Wiley & Sons, Ltd.

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