No conflict of interest was declared.
Changes in use of disease-modifying anti-rheumatic drugs in Australia over the period 1992–2004†
Article first published online: 15 MAY 2006
Copyright © 2006 John Wiley & Sons, Ltd.
Pharmacoepidemiology and Drug Safety
Volume 15, Issue 7, pages 462–468, July 2006
How to Cite
Chan, V. and Tett, S. E. (2006), Changes in use of disease-modifying anti-rheumatic drugs in Australia over the period 1992–2004. Pharmacoepidem. Drug Safe., 15: 462–468. doi: 10.1002/pds.1256
- Issue published online: 29 JUN 2006
- Article first published online: 15 MAY 2006
- Manuscript Accepted: 7 FEB 2006
- Manuscript Revised: 13 OCT 2005
- Manuscript Received: 7 JUL 2005
- rheumatoid arthritis;
- disease-modifying anti-rheumatic drugs;
- defined daily dose
Evidence is growing that early use of disease-modifying anti-rheumatic drugs (DMARDs) and combinations of these drugs provide optimal care for people with rheumatoid arthirits. The aim of this study was to describe objectively the pattern of consumption of DMARDs in the Australian community (community-based prescribing, specialist and general practitioner) 1992–2004, and to compare this with prescribing patterns reported in other countries.
Dispensing statistics from the Pharmaceutical Benefit Scheme (PBS—Australia's universal prescription subsidy scheme) were analysed and temporal trends evaluated. Drug consumption was calculated as the number of dispensed defined daily doses (DDD)/1000 inhabitants/day (WHO ATC/DDD classification 2005).
The consumption of DMARDs in the Australian community increased steadily from 2.6 DDD/1000 inhabitants/day in 1992 to 5.5 DDD/1000 inhabitants/day. Over the period 1992–2004, methotrexate (MTX) was the most commonly used DMARD (from 0.6 to 3.0 DDD/1000 inhabitants/day). Consumption of gold (parenteral and oral) and penicillamine declined during this time. The inclusion of leflunomide on the PBS in 2000 contributed to the increase in DMARD usage.
Use of DMARDs within the Australian community has increased in recent years, coinciding with the change in guidelines for therapy for rheumatoid arthritis (RA) to earlier use of DMARDs and the more common use of combinations. This study used DDD methodology to quantify trends for DMARD consumption and these trends are broadly consistent with international prescribing patterns assessed using different methodologies. Copyright © 2006 John Wiley & Sons, Ltd.