The results presented in this manuscript have been approved by all authors. None of the material in this manuscript has been published previously in any form and none of this material is currently under consideration for publication elsewhere. This includes symposia and proceedings of meetings and preliminary publications of any kind except an abstract of 400 words or less. All authors fulfilled the criteria of authorship, reviewed and approved the paper, and attest to the integrity of the work submitted.
In-hospital use of opioids increases rate of coded postoperative paralytic ileus†
Version of Record online: 30 OCT 2006
Copyright © 2006 John Wiley & Sons, Ltd.
Pharmacoepidemiology and Drug Safety
Volume 16, Issue 6, pages 668–674, June 2007
How to Cite
Goettsch, W. G., Sukel, M. P. P., van der Peet, D. L., van Riemsdijk, M. M. and Herings, R. M. C. (2007), In-hospital use of opioids increases rate of coded postoperative paralytic ileus. Pharmacoepidem. Drug Safe., 16: 668–674. doi: 10.1002/pds.1338
- Issue online: 4 JUN 2007
- Version of Record online: 30 OCT 2006
- Manuscript Accepted: 7 SEP 2006
- Manuscript Revised: 8 AUG 2006
- Manuscript Received: 6 JUN 2006
- GlaxoSmithKline Netherlands, Zeist, the Netherlands
- postoperative paralytic ileus;
- prolonged postoperative ileus;
To determine the association between opioid use and the occurrence of postoperative paralytic ileus (POI) after different types of surgery.
The PHARMO database was used to perform a case control study in which intramural drug utilisation data were linked to hospital discharge diagnoses. All patients admitted for digestive, abdominal or genito-urinary surgeries were selected in 1998–2003. Cases with coded POI (ICD-9-CM 560.1 and 564.4) and controls with no POI were matched 1:10. The association between coded POI and opioid use was assessed using conditional logistic regression.
In 0.2% of all admissions (total of 180,279), patients developed POI and in 18% of all admissions, patients received opioids. Three hundred and sixty-six cases with POI were selected with their matching controls. The use of (nico)morphine was associated with the risk for developing POI (odds ratio (OR) 12.1, 95% confidence interval (CI) 5.4–27.1). The association between opioids and POI was most obvious in patients with abdominal surgery (OR 33.8, 95%CI 6.2–184.6) and patients without colon/colorectal/rectal tumours (OR 13.2, 95%CI 5.7–30.3).
This study demonstrated a distinct association between the use of opioids, in particular natural opium alkaloids, and the risk for coded POI. Copyright © 2006 John Wiley & Sons, Ltd.