No conflict of interest was declared.
Lack of effect of influenza immunisation on anticoagulant control in patients on long-term warfarin†
Article first published online: 17 NOV 2006
Copyright © 2006 John Wiley & Sons, Ltd.
Pharmacoepidemiology and Drug Safety
Volume 16, Issue 7, pages 786–789, July 2007
How to Cite
MacCallum, P., Madhani, M., Mt-Isa, S. and Ashby, D. (2007), Lack of effect of influenza immunisation on anticoagulant control in patients on long-term warfarin. Pharmacoepidem. Drug Safe., 16: 786–789. doi: 10.1002/pds.1347
- Issue published online: 28 JUN 2007
- Article first published online: 17 NOV 2006
- Manuscript Revised: 4 OCT 2006
- Manuscript Accepted: 4 OCT 2006
- Manuscript Received: 27 JUN 2006
- influenza vaccine
The effect of influenza vaccination on oral anticoagulant control is uncertain but important to establish since anticoagulants are widely used and most patients taking them are candidates for immunisation because of age or underlying cardiac disease. We therefore prospectively evaluated the effect of influenza vaccination on International Normalised Ratio (INR) control in patients on long-term warfarin.
We undertook a prospective audit of patients on long-term warfarin attending a single hospital anticoagulant clinic who reported receiving influenza vaccination within the 10 days prior to a clinic visit. We compared the stability of anticoagulant control in the 12 months prior to and 10 days after immunisation, restricting analysis to those patients whose warfarin dosage was unchanged before and after vaccination.
Of 106 consecutive patients who reported receiving influenza vaccination within the 10 days prior to a clinic visit, results were evaluable in 78 because the dose of warfarin was unchanged before and after vaccination. Influenza immunisation had no apparent effect on anticoagulant control. No bleeding or thrombotic complications were reported.
Our findings suggest that it is not necessary to routinely monitor the INR more closely after influenza vaccination. Copyright © 2006 John Wiley & Sons, Ltd.