No conflict of interest was declared.
Antipyretic drug use in children in French office based medical practice†
Article first published online: 1 JUN 2007
Copyright © 2007 John Wiley & Sons, Ltd.
Pharmacoepidemiology and Drug Safety
Volume 16, Issue 7, pages 812–817, July 2007
How to Cite
Deligne, J., Grimaldi, L., Jonville-Béra, A.-P., Giraudeau, B., Blum-Boisgard, C. and Autret-Leca, E. (2007), Antipyretic drug use in children in French office based medical practice. Pharmacoepidem. Drug Safe., 16: 812–817. doi: 10.1002/pds.1422
- Issue published online: 28 JUN 2007
- Article first published online: 1 JUN 2007
- Manuscript Accepted: 7 APR 2007
- Manuscript Revised: 3 APR 2007
- Manuscript Received: 19 JUN 2006
- antipyretic combination;
To analyse antipyretics (APs) prescriptions profile in children, particularly the frequency of AP combinations.
APs (acetylsalicylic acid, paracetamol, ibuprofen or ketoprofen) prescribed to children below 12 years and refunded by a public health insurer in 2003, throughout France, were examined.
A total of 513 034 prescriptions were refunded for 240 720 children. The mean number of AP prescriptions per child was the highest in children aged 6 months to 2 years. Paracetamol was the main AP prescribed, but its prescription declined with age, from 90.8% below 3 months old to 57.4% between 6 and 12 years old. Ibuprofen-only prescriptions were rare below 3 months and maximal between 2 and 6 years. The ibuprofen/paracetamol combination was prescribed from 6 months old, and its frequency was maximal between 2 and 6 years old (21.7%).
The clear predominance of paracetamol prescriptions suggests that French prescribers are relatively aware of the relative risk-benefit ratio of the different APs. Studies are required to determine if the APs are prescribed to be used alternately or when a monotherapy fails. Guidelines to manage fever in children are needed in France to restrict APs combination to the case of paracetamol failure. Copyright © 2007 John Wiley & Sons, Ltd.