The authors declare no conflict of interest.
Adverse drug reactions induced by cardiovascular drugs in cardiovascular care unit patients†
Article first published online: 9 FEB 2010
Copyright © 2010 John Wiley & Sons, Ltd.
Pharmacoepidemiology and Drug Safety
Volume 19, Issue 9, pages 889–894, September 2010
How to Cite
Mohebbi, N., Shalviri, G., Salarifar, M., Salamzadeh, J. and Gholami, K. (2010), Adverse drug reactions induced by cardiovascular drugs in cardiovascular care unit patients. Pharmacoepidem. Drug Safe., 19: 889–894. doi: 10.1002/pds.1916
- Issue published online: 25 AUG 2010
- Article first published online: 9 FEB 2010
- Manuscript Accepted: 8 DEC 2009
- Manuscript Revised: 3 DEC 2009
- Manuscript Received: 4 AUG 2009
- adverse drug reaction;
- cardiovascular drugs;
- CCU patients
To detect the type, rate, seriousness, and preventability of adverse drug reactions (ADRs) attributable to cardiovascular drugs in cardiovascular care unit; and to determine the relationship between patient factors and detected ADRs.
Patients admitted to cardiovascular care units in Tehran Heart Center over an eight month period who received at least one cardiovascular drug were eligible to enter the study. ADRs were recorded based on information collected by interviewing patients, reviewing patients' charts, laboratory test monitoring, and confirmation by physicians. The World Health Organization definition for ADR, its seriousness and casualty criteria, was used to evaluate the reactions. The preventability was estimated based on Schumock and Thornton questioning. The relationship between possible risk factors and ADRs occurrence were assessed by statistical analysis.
During the study period, 677 patients entered the study. A total number of 189 ADRs were registered of which 22.2% were serious. The highest ADR rates were observed with Streptokinase (59.3%). The rate of preventable ADRs was 6.9%. Multivariate logistic regression analysis showed that patients with lower weight (OR = 0.95, 95%CI: 0.9–0.99) and patients with smoking history who had concurrent diseases (OR = 8.72, 95%CI: 1.53–49.52) had a higher risk of experiencing ADRs.
The rate of ADRs induced by cardiovascular drugs in this study was 24.2%. This study has shown that anti-arrhythmic and thrombolytic agents need more attention. Copyright © 2010 John Wiley & Sons, Ltd.