Variations and determinants of antibiotic consumption in Hungarian adult intensive care units
Version of Record online: 28 JUL 2011
Copyright © 2011 John Wiley & Sons, Ltd.
Pharmacoepidemiology and Drug Safety
Volume 21, Issue 1, pages 104–109, January 2012
How to Cite
Benkő, R., Matuz, M., Pető, Z., Bogár, L., Viola, R., Doró, P., Soós, G. and Hajdú, E. (2012), Variations and determinants of antibiotic consumption in Hungarian adult intensive care units. Pharmacoepidem. Drug Safe., 21: 104–109. doi: 10.1002/pds.2192
- Issue online: 4 JAN 2012
- Version of Record online: 28 JUL 2011
- Manuscript Accepted: 25 MAY 2011
- Manuscript Revised: 18 APR 2011
- Manuscript Received: 16 FEB 2011
- antibiotic use;
- adult intensive care units;
- determinants of use;
- DDD per 100 patient-days
The aim of this work was to study the use of systemic antibacterials and its possible determinants in Hungarian intensive care units (ICUs).
Hospital pharmacy. departments provided package level dispensing data for their corresponding ICU (2006). Data were converted into defined daily doses (DDDs) and expressed as DDD per 100 patient-days and DDD per 100 admissions. Antibiotics were ranked by volume of DDDs, and the agents responsible for 90% of total use (DU90%) were noted. To explore differences and relationships between antibiotic use and antibiotic policy elements/ICU characteristics, the analysis of variances or the Pearson correlation analysis was performed.
Valid data were obtained for 44 ICUs. Antibiotic use varied widely (from 27.9 to 167.8 DDD per 100 patient-days and from 104.7 to 1784.6 DDD per 100 admissions). In total, 11–34 different antibacterials per ICUs were used, of which, 5–15 were in the DU90% segment. The proportional use of parenteral agents ranged from 46.2 to 98.3%. The mean of overall antibiotic use was highest for penicillins with beta-lactamase inhibitors, followed by quinolones and third-generation cephalosporins. Of the studied factors, only the ICU category (i.e., level of care) showed significant association with total antibacterial use.
The striking differences in total antibiotic use and the extensive use of the oral agents in some ICUs may indicate room for improvement. As none of the antibiotic policy elements were accompanied by lower antibiotic use in the pooled analysis, it suggests that—beside the ICU category—other unrevealed factors determine antibiotic use. Copyright © 2011 John Wiley & Sons, Ltd.