Additional supporting information may be found in the online version of this article:

pds_3334_sm_appendix.docWord document66K

A1.0. Defining incident users in prospective studies: trade-offs for internal validity and applicability

A2.0. Advantages of the incident user design for improving internal validity

A3.0. Trade-offs of the incident user design

A4.0. Incident user designs in the context of other design and analysis choices

A5.0. Priority research gaps

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