A survey of adult awareness and use of medicine containing acetaminophen
Article first published online: 13 AUG 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Pharmacoepidemiology and Drug Safety
Volume 22, Issue 3, pages 229–240, March 2013
How to Cite
Boudreau, D. M., Wirtz, H., Von Korff, M., Catz, S. L., St. John, J. and Stang, P. E. (2013), A survey of adult awareness and use of medicine containing acetaminophen. Pharmacoepidem. Drug Safe., 22: 229–240. doi: 10.1002/pds.3335
- Issue published online: 1 MAR 2013
- Article first published online: 13 AUG 2012
- Manuscript Accepted: 17 JUL 2012
- Manuscript Revised: 5 JUL 2012
- Manuscript Received: 13 DEC 2011
- Group Health Research Institute and Johnson and Johnson, Inc
- medication use;
- drug safety;
- claims data;
To compare awareness, use of acetaminophen, and preferences for receiving information aimed at reducing acetaminophen overdose.
A survey of health plan enrollees identified from automated pharmacy data who were long-term and acute users of opioids with acetaminophen (n = 720 each cohort), and a general population cohort (n = 360) during the 2010–2011 cold/flu season. A 74% response rate was achieved. Differences were tested across the three cohorts, and by level of education, using age-adjusted regression models.
Use of over-the-counter or prescription medicine containing acetaminophen in the prior 2 weeks was reported by 84% in the long-term opioid cohort, 76% in the acute opioid cohort, and 36% in the general population, but use of over-the-counter medicine with acetaminophen did not differ across the cohorts (30–34%). All three cohorts were unlikely to correctly identify drugs containing acetaminophen, but the opioid cohorts performed slightly better than the general population. Those with higher education performed slightly better when asked to identify acetaminophen products than those with no college education. The average usual daily acetaminophen dose (mg/day) reported was highest in the long-term opioid cohort (1185), followed by the acute opioid cohort (1010), and the general population (891)—p < 0.001. Estimated supratherapeutic exposure (>4000 mg/day) was rare but three to five times more common in the opioid cohorts than in the general population.
Acetaminophen use is common, and supratherapeutic exposure may be of concern in users of opioids. Knowledge of which drugs contain acetaminophen appears inadequate; better labeling and proactive education from professionals may be impactful. Copyright © 2012 John Wiley & Sons, Ltd.