Different indications, warnings and precautions, and contraindications for the same drug—an international comparison of prescribing information for commonly used psychiatric drugs
Article first published online: 26 DEC 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Pharmacoepidemiology and Drug Safety
Volume 22, Issue 3, pages 329–333, March 2013
How to Cite
Pfistermeister, B., Schenk, C., Kornhuber, J., Bürkle, T., Fromm, M. F. and Maas, R. (2013), Different indications, warnings and precautions, and contraindications for the same drug—an international comparison of prescribing information for commonly used psychiatric drugs. Pharmacoepidem. Drug Safe., 22: 329–333. doi: 10.1002/pds.3389
- Issue published online: 1 MAR 2013
- Article first published online: 26 DEC 2012
- Manuscript Accepted: 19 NOV 2012
- Manuscript Revised: 8 NOV 2012
- Manuscript Received: 9 JUL 2012
- German Federal Ministry of Education and Research (BMBF). Grant Number: 01EX1015B
- prescribing information;
- Summary of Product Characteristics;
- antidepressive agents;
- international comparison;
- serotonin agents;
We aim to derive an internationally applicable data set to improve prescription safety of psychiatric drugs.
We performed an in-depth analysis of the concordance of prescribing information of 10 key psychiatric drugs across four major drug markets with regard to indications, warnings and precautions, and contraindications.
The individual prescribing information covered on average 71.4 ± 30.3% of all named indications, 59.5 ± 17.1% of all potential warnings and precautions and 70.1 ± 24.4% of all applicable contraindications.
This substantial variation in key prescribing information across countries highlights the need for a better international cooperation and standardization of prescribing information. Copyright © 2012 John Wiley & Sons, Ltd.