Different indications, warnings and precautions, and contraindications for the same drug—an international comparison of prescribing information for commonly used psychiatric drugs

Authors

  • Barbara Pfistermeister,

    1. Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
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  • Christian Schenk,

    1. Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
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  • Johannes Kornhuber,

    1. Department of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
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  • Thomas Bürkle,

    1. Chair of Medical Informatics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
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  • Martin F Fromm,

    1. Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
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  • Renke Maas

    Corresponding author
    • Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
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Correspondence to: Renke Maas, Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-University Erlangen-Nuremberg, Fahrstraße 17, 91054 Erlangen, Germany. E-mail: renke.maas@pharmakologie.uni-erlangen.de

ABSTRACT

Purpose

We aim to derive an internationally applicable data set to improve prescription safety of psychiatric drugs.

Methods

We performed an in-depth analysis of the concordance of prescribing information of 10 key psychiatric drugs across four major drug markets with regard to indications, warnings and precautions, and contraindications.

Results

The individual prescribing information covered on average 71.4 ± 30.3% of all named indications, 59.5 ± 17.1% of all potential warnings and precautions and 70.1 ± 24.4% of all applicable contraindications.

Conclusion

This substantial variation in key prescribing information across countries highlights the need for a better international cooperation and standardization of prescribing information. Copyright © 2012 John Wiley & Sons, Ltd.

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