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Additional supporting information may be found in the online version of this article:

Appendix Section 1: Figure 1. Flow diagram of identification of gold standard positive and negative AEs.

Appendix Section 2: Table 1. List of 19 tested medicines and tested adverse events for sequence symmetry analysis.

Appendix Section 3: Table 2. List of tested adverse events and their indicators.

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Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.