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Additional supporting information may be found in the online version of this article:

Supplemental Table 1: The definition of the composite outcome (reaching the first of GFR event or ESRD)

Supplemental Table 2: Definitions for severe medical conditions. One inpatient or two outpatient diagnoses for one of these conditions or fill of a listed medication in the baseline year excluded patients from cohort

Supplemental Table 3: Definition of cardiovascular disease

Supplemental Table 4: Risk for the composite outcome of GFR event, ESRD or death in the presence of an unmeasured confounder with a hazard ratio of 1.25 for CVD and various prevalence levels of the confounder, by exposure group

Supplemental Table 5: Risk for the composite outcome of GFR event, ESRD or death in the presence of an unmeasured confounder with a hazard ratio of 2 for CVD and various prevalence levels of the confounder, by exposure group

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pds3432-sup-0001-pds_3432_supplementary material.docWord document88KSupporting Information

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