Validity of congenital malformation diagnostic codes recorded in Québec's administrative databases

Authors

  • Lucie Blais,

    Corresponding author
    1. Research Center, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada
    2. Endowment Pharmaceutical Chair AstraZeneca in Respiratory Health, Montréal, Québec, Canada
    • Faculty of Pharmacy, Université de Montréal, Montréal, Québec, Canada
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  • Anick Bérard,

    1. Faculty of Pharmacy, Université de Montréal, Montréal, Québec, Canada
    2. CHU Mère-enfant Ste-Justine, Montréal, Québec, Canada
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  • Fatima-Zohra Kettani,

    1. Faculty of Pharmacy, Université de Montréal, Montréal, Québec, Canada
    2. Research Center, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada
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  • Amélie Forget

    1. Faculty of Pharmacy, Université de Montréal, Montréal, Québec, Canada
    2. Research Center, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada
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  • Oral presentations: 8e Colloque Annuel du RQRUM May 29–30, 2012, Québec City, Québec, Canada (http://www.reseau-medicaments.qc.ca/evenements/index.php?id=51); ISPE 28th International Conference on Pharmacoepidemiology and Therapeutic Risk Management, August 23–26, 2012 CCIB Barcelona, Spain (http://www.pharmacoepi.org/meetings/28ICPE/index.cfm)

  • Poster presentations:

    Canadian Association for Population Therapeutics (CAPT) 2012 Annual Conference, May 6–8, 2012, Montréal, Québec, Canada (http://www.capt-actp.com/conference/); 52nd Annual Meeting of the Teratology Society, June 23–27, 2012, Baltimore, Maryland, USA (http://teratology.org/meetings/2012/ag_ov.asp)

Correspondence to: L. Blais, Université de Montréal, Faculté de Pharmacie, C.P. 6128, Succursale Centre-ville, Montréal (Québec), Canada H3C 3J7. E-mail: lucie.blais@umontreal.ca

ABSTRACT

Purpose

To assess the validity of the diagnostic codes of congenital malformations (CMs) recorded in two of Québec's administrative databases.

Methods

A cohort of pregnancies and infants born to asthmatic and non-asthmatic women in 1990–2002 was reconstructed using Québec's administrative databases. From this cohort, we selected 269 infants with a CM and 144 without CM born to asthmatic women, together with 284 and 138 infants, respectively, born to non-asthmatic women. The diagnoses of CMs recorded in the databases were compared with the diagnoses written by the physicians in the infants' medical charts. The positive predictive values (PPV) and negative predictive values (NPV) for all, major, and several specific CMs were estimated.

Results

The PPVs for all CMs and major CMs were 82.2% (95% confidence interval (CI): 78.5%–85.9%) and 78.1% (74.1%–82.1%), respectively, in the asthmatic group and were 79.2% (75.4%–83.1%) and 69.0% (64.6%–73.4%), respectively, in the non-asthmatic group. PPVs >80% were found for several specific CMs, including cardiac, cleft, and limb CMs in both groups. The NPV for any CM was 88.2% (95% CI: 85.1%–91.3%) in the asthmatic group and 94.2% (92.2%–96.2%) in the non-asthmatic group.

Conclusions

Québec's administrative databases are valid tools for epidemiological research of CMs. The results were similar between infants born to women with and without asthma. Copyright © 2013 John Wiley & Sons, Ltd.

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