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Additional supporting information may be found in the online version of this article:

Appendix Table 1: Grouping of medications into centrally acting or non-centrally acting ACEIs

Appendix Table 2: ADRD medications

Appendix Table 3: Propensity score specification for matching incident users

Appendix Table 4: Propensity score specification for matching prevalent users

Appendix Table 5: Characteristics of unmatched and matched patients in the prevalent user cohort

Appendix Table 6: Comparison of the balance of explanatory variables across levels of the instrumental variables, prevalent user cohort

Appendix Table 7: Characteristics of unmatched and matched patients in the incident user cohort

Appendix Table 8: Comparison of the balance of explanatory variables across levels of the instrumental variables, incident user cohort

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