Prescriptions for category D and X drugs during pregnancy in Taiwan: a population-based study
Article first published online: 28 FEB 2014
Copyright © 2014 John Wiley & Sons, Ltd.
Pharmacoepidemiology and Drug Safety
Volume 23, Issue 10, pages 1029–1034, October 2014
How to Cite
2014), Prescriptions for category D and X drugs during pregnancy in Taiwan: a population-based study, Pharmacoepidemiol Drug Saf, 23; pages 1029–1034, doi: 10.1002/pds.3599, , , and (
- Issue published online: 14 OCT 2014
- Article first published online: 28 FEB 2014
- Manuscript Revised: 22 JAN 2014
- Manuscript Accepted: 22 JAN 2014
- Manuscript Received: 4 SEP 2013
- category D and X drugs;
- prescribing behavior;
This study aimed to investigate the most prescribed medications and principle diagnoses for category D and X drugs during pregnancy using a population-based dataset in Taiwan.
The data for the present study were sourced from the Taiwan Longitudinal Health Insurance Database 2000. We selected 14 125 women who had live singleton births between 1 January 2009 and 31 December 2011. In total, 217 226 prescriptions prescribed to these pregnant women were identified.
Of the total 217 226 prescriptions, 1.1% were category D or X drugs; in the first, second, and third trimesters of pregnancy, 1.8%, 0.7%, and 0.5% of prescriptions were category D or X drugs, respectively. Progestins (15.3%) and propylthiouracil (10.7%) were the two most frequently prescribed category D or X drugs during pregnancy. In particular, progestins (20.4%) and estrogens (15.6%) were the most frequently prescribed category D or X drug in the first trimester of pregnancy. Propylthiouracil was the most prescribed category D or X drug in the second (20.3%) and third trimesters (23.1%) of pregnancy, respectively. The most common principal diagnosis during pregnancy was “disorders of menstruation and other abnormal bleeding from the female genital tract” (22% of all principal diagnoses for prescribing category D and X drugs).
Our study found that the physicians obviously reduced the use of category D and X drugs for women after becoming aware that they were pregnant. Copyright © 2014 John Wiley & Sons, Ltd.