Signal generation and clarification: use of case–control data
Article first published online: 18 JUL 2001
Copyright © 2001 John Wiley & Sons, Ltd.
Pharmacoepidemiology and Drug Safety
Volume 10, Issue 3, pages 197–203, May 2001
How to Cite
Kaufman, D. W., Rosenberg, L. and Mitchell, A. A. (2001), Signal generation and clarification: use of case–control data. Pharmacoepidem. Drug Safe., 10: 197–203. doi: 10.1002/pds.571
- Issue published online: 18 JUL 2001
- Article first published online: 18 JUL 2001
- Manuscript Accepted: 23 OCT 2000
- Manuscript Received: 29 SEP 2000
- hypothesis generation;
Case-control surveillance systems are useful for ‘signal’ generation, i.e., signaling potential previously unidentified adverse effects of drugs. Two systems currently in operation, the Slone Epidemiology Unit's Case-Control Surveillance and the Birth Defects Study, have monitored drug effects since 1976. With extensive information on the diagnoses and covariates, the systems have the capacity to carry out in-depth analyses in which the outcome measure is more specifically defined and in which confounding is controlled, thus reducing the possibility of false alarms. Copyright © 2001 John Wiley & Sons, Ltd.