This article is a US Government work and is in the public domain in the USA.
Ovarian cancer risk and use of phenolphthalein-containing laxatives†
Article first published online: 26 MAR 2003
Copyright © 2003 John Wiley & Sons, Ltd.
Pharmacoepidemiology and Drug Safety
Volume 13, Issue 1, pages 35–39, January 2004
How to Cite
Cooper, G. S., Longnecker, M. P. and Peters, R. K. (2004), Ovarian cancer risk and use of phenolphthalein-containing laxatives. Pharmacoepidem. Drug Safe., 13: 35–39. doi: 10.1002/pds.824
- Issue published online: 24 DEC 2003
- Article first published online: 26 MAR 2003
- Manuscript Accepted: 3 JAN 2003
- Manuscript Revised: 19 NOV 2002
- Manuscript Received: 6 JUN 2002
- Division of Intramural Research, National Institute of Environmental Health Sciences. Grant Number: CA 17054, CA 14089
- National Institutes of Health. Grant Number: CA 61132
- ovarian cancer;
Experimental studies in rodents demonstrated the carcinogenic potential of phenolphthalein, the active ingredient in some laxatives, administered at doses similar to the dose that could be used by humans. Ovarian cancer was one of the cancers observed in these studies. We examined the association between epithelial ovarian cancer and use of phenolphthalein-containing laxatives in a population-based case-control study.
The study includes 356 epithelial ovarian cancer cases (256 invasive, 100 borderline) and 424 controls. Cases were identified through a population-based registry in Los Angeles County in 1992–1998, and controls were matched to cases by age, race/ethnicity and neighborhood. Data on laxative use (specific brands, frequency of use, usual dose) were obtained by structured in-person interview.
Compared to women who never used a laxative, ever use of a phenolphthalein-containing laxative was not associated with an increased risk of invasive ovarian cancer (odds ratio (OR) 1.1, 95% confidence interval (CI) 0.75, 1.5) or of borderline ovarian cancer (OR 0.75, 95%CI 0.37, 1.5). Total days used, mean number of pills per day and cumulative dose were also unrelated to risk.
This study provides some assurance that phenolphthalein-containing laxatives do not increase the risk of ovarian cancer in humans. These findings are of particular importance to those countries in which phenolphthalein is still used in over-the-counter medications. Published in 2003 John Wiley & Sons, Ltd.