Increased suicide attempt rate among patients interrupting use of atypical antipsychotics
Article first published online: 6 MAY 2003
Copyright © 2003 John Wiley & Sons, Ltd.
Pharmacoepidemiology and Drug Safety
Volume 12, Issue 5, pages 423–424, July/August 2003
How to Cite
Herings, R. M. C. and Erkens, J. A. (2003), Increased suicide attempt rate among patients interrupting use of atypical antipsychotics. Pharmacoepidem. Drug Safe., 12: 423–424. doi: 10.1002/pds.837
- Issue published online: 11 JUL 2003
- Article first published online: 6 MAY 2003
- Manuscript Accepted: 18 FEB 2003
- Manuscript Received: 7 DEC 2002
- Janssen-Cilag bv, The Netherlands
- suicide attempt;
- atypical antipsychotic drug;
The aim of the study is to investigate whether patients at risk to commit suicide could be identified based on their drug refill patterns.
Data for this study were obtained from the PHARMO system comprising drug-dispensing data linked to hospital discharge records. All patients aged 15–45 years, suspected to suffer from schizophrenia and exclusive users of olanzapine or risperidone were selected. The use of antipsychotics was converted into treatment episodes of uninterrupted use. Therapy non-compliance was defined as a drug holiday of at least 30 days. The follow-up started with a treatment episode of at least 90 days. Relative risks for suicide attempts and 95% confidence limits due to drug holidays were estimated using Poisson regression analyses.
Of 603 patients, 33% interrupted treatment for at least 30 days. An increased suicide attempt rate was observed when comparing uninterrupted and interrupted drug use (20.0/1000 person years vs 72.1/1000 person years, respectively). A four-fold increased risk for attempting suicide among patients with drug holidays was found (RRadjusted for age and gender 4.2, 95%CI: 1.7–10.1) compared to patients without drug holidays.
Patients who do not refill atypical antipsychotics in time can be identified in the pharmacy and are most likely those with an increased risk to commit suicide. Copyright © 2003 John Wiley & Sons, Ltd.