Unconditional support for the data analyses for the present article was supplied by McNeil Consumer & Specialty Pharmaceuticals, Fort Washington, PA, USA.
A case-control study of acetaminophen use in relation to the risk of first myocardial infarction in men†
Article first published online: 3 JUN 2003
Copyright © 2003 John Wiley & Sons, Ltd.
Pharmacoepidemiology and Drug Safety
Volume 12, Issue 6, pages 459–465, September 2003
How to Cite
Rosenberg, L., Rao, R. S. and Palmer, J. R. (2003), A case-control study of acetaminophen use in relation to the risk of first myocardial infarction in men. Pharmacoepidem. Drug Safe., 12: 459–465. doi: 10.1002/pds.867
- Issue published online: 12 AUG 2003
- Article first published online: 3 JUN 2003
- Manuscript Revised: 3 MAY 2003
- Manuscript Accepted: 8 APR 2003
- Manuscript Received: 1 OCT 2002
- National Institute for Child Health and Human Development. Grant Number: N01-HD-0-2810
- myocardial infarction
Experimental evidence raises the possibility that acetaminophen use could reduce the risk of myocardial infarction (MI). We assessed the relation of acetaminophen use, and also of aspirin use, to first MI in a case-control study.
Data on analgesic use and other factors were collected in a hospital-based case-control study of first MI in men under 55 years of age conducted from 1980 to 1983. We compared 2035 men with first MIs to 2656 control men admitted for conditions unrelated to analgesic use. Odds ratios (ORs) for acetaminophen use relative to nonuse were estimated with logistic regression analysis, controlling for major MI risk factors.
The OR was 0.9 (95% confidence interval (CI): 0.6–1.3) for acetaminophen use at least once a week for at least 3 months, 0.7 (95%CI: 0.4–1.1) for daily use for at least 3 months, and 0.5 (95%CI: 0.2–1.6) for daily use for at least 5 years. In analyses of aspirin use, the OR was 0.9 (95%CI: 0.7–1.2) for use at least once a week for at least 3 moths, 0.9 (95%CI: 0.6–1.2) for daily use lasting at least 3 months, 0.6 (95%CI: 0.4–1.1) for daily use for at least 5 years, and 0.4 (95%CI: 0.2–1.0) for daily use for at least 10 years.
While our results raise the possibility of a protective effect of long-term regular acetaminophen use against first MI, they are compatible with no effect. The data suggest a potential protective effect of long-term regular aspirin use. Copyright © 2003 John Wiley & Sons, Ltd.