No conflict of interest was declared.
Article first published online: 27 APR 2004
Copyright © 2004 John Wiley & Sons, Ltd.
Pharmacoepidemiology and Drug Safety
Volume 14, Issue 1, pages 17–24, January 2005
How to Cite
French, D. D., Campbell, R., Spehar, A. and Angaran, D. M. (2005), Benzodiazepines and injury: a risk adjusted model. Pharmacoepidem. Drug Safe., 14: 17–24. doi: 10.1002/pds.967
The views expressed in this article are those of the authors and do not necessarily represent the views of the Department of Veterans Affairs.
- Issue published online: 13 DEC 2004
- Article first published online: 27 APR 2004
- Manuscript Accepted: 17 JAN 2004
- Manuscript Revised: 13 JAN 2004
- Manuscript Received: 17 JUN 2003
- Department of Veterans Affairs
- Veterans Health Administration (VHA)
- risk adjustment;
- wounds and injuries;
- practice guidelines;
- patient safety
Benzodiazepines (BZD) are one class of medications that are generally acknowledged to be a risk factor for injuries.
Our objective was to link outpatient prescription data with clinical data in order to develop a risk adjusted binary model that associates BZD usage with the risk for a healthcare encounter for an injury.
In total, 3 years of outpatient BZD prescription data, totaling 133 872 outpatient BZD prescriptions for 13 745 patients for a VA medical center, were combined with data from inpatient and outpatient administrative databases. The model incorporated Elixhauser comorbidity measures with 1-year look back period, along with hospital discharges, marital status, age, mean arterial pressure and body mass index. The model also included the dose of the drug, converted to valium equivalents and its duration. The model was analyzed using generalized estimation equations (GEE).
Dose, duration, discharges and various comorbidities were associated with an increased risk for injury, while being married reduced the risk. Increased body mass was associated with increased injury risk. Increased mean arterial pressure was associated with decreased risk.
These findings offer guidance on how specific combinations of risk factors and potential protective effects may impact accidental injury risk. Clinicians prescribing or adjusting BZDs can use these results to more accurately tailor medication regimens for a patient. Our findings suggest that clinicians should also consider the nature of the social support system available to the patient in assessing total injury risk. Copyright © 2004 John Wiley & Sons, Ltd.