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Structural changes and biodegradation of PLLA, PCL, and PLGA sponges during in vitro incubation

Authors

  • Taiyo Yoshioka,

    1. Biomaterials Center, National Institute for Materials Science, Tsukuba, Ibaraki 305-0044, Japan
    Current affiliation:
    1. Material Sciences Center, Philipps University, Hans-Meerwein-Str, Marburg D-35032, Germany
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  • Fumiko Kamada,

    1. Biomaterials Center, National Institute for Materials Science, Tsukuba, Ibaraki 305-0044, Japan
    2. Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-0003, Japan
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  • Naoki Kawazoe,

    1. Biomaterials Center, National Institute for Materials Science, Tsukuba, Ibaraki 305-0044, Japan
    2. International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science, Tsukuba, Ibaraki 305-0044, Japan
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  • Tetsuya Tateishi,

    1. Biomaterials Center, National Institute for Materials Science, Tsukuba, Ibaraki 305-0044, Japan
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  • Guoping Chen

    Corresponding author
    1. Biomaterials Center, National Institute for Materials Science, Tsukuba, Ibaraki 305-0044, Japan
    2. Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-0003, Japan
    3. International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science, Tsukuba, Ibaraki 305-0044, Japan
    • Biomaterials Center, National Institute for Materials Science, Tsukuba, Ibaraki 305-0044, Japan
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Abstract

The structural changes and degradation behaviors of poly(L-lactic acid) (PLLA) and poly(ε-caprolactone) (PCL) sponges were studied by incubation in phosphate buffer solution and compared with those of previously reported poly(lactic-co-glycolic acid) (PLGA) sponge. The changes of pH, weight, molecular weight, crystallinity, and thermal properties of glass transition and melting were measured. The influence of incubation temperature on the structural change of each type of sponge was investigated in details. During incubation, the PLLA sponge showed secondary crystallization, the PCL sponge showed lamellar thickening, and the PLGA sponge showed physical aging. Depending on the type of biodegradable polymers, the incubation temperature caused different structural changes during the incubation and the structural changes influenced several degradation behaviors. POLYM. ENG. SCI., 50:1895–1903, 2010. © 2010 Society of Plastics Engineers

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