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Photo-responsive monoolein cubic phase incorporating hydrophobically modified poly(vinyl alcohol)–coumarin conjugate

Authors

  • Mi Sun Lee,

    1. Department of Medical Biomaterials Engineering, College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Kangwon-do 200-701, Korea
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  • Jin-Chul Kim

    Corresponding author
    1. Department of Medical Biomaterials Engineering, College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Kangwon-do 200-701, Korea
    • Department of Medical Biomaterials Engineering, College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Kangwon-do 200-701, Korea. E-mail: jinkim@kangwon.ac.kr

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Abstract

Photo-responsive monoolein cubic phases were developed by immobilizing hydrophobically modified poly (vinyl alcohol)–epoxypropoxy coumarin conjugate (HmPVA–EPC) in the water channels of the cubic phase. On the NMR spectrum of HmPVA-EPC, the molar ratio of PVA/decanoyl chloride (a hydrophobic anchor)/EPC was determined to be about 1:0.64:1.45. The interfacial activity of PVA–EPC conjugate was much lower than that of PVA, but the interfacial activity of HmPVA–EPC was as high as that of PVA. The critical micelle concentrations of HmPVA–EPC and PVA were about 0.005%. Under the ultraviolet (UV) irradiation (λ = 254 nm), EPC residues of HmPVA were readily dimerized and the dimerization degree in 180 min was about 33%. The irradiation of UV light had no significant effect on the release of fluorescein isothiocyanate–dextran (a fluorescence marker) from cubic phase free of polymer and cubic phase incorporating HmPVA, but it suppressed the release from cubic phase incorporating HmPVA–EPC. The photo crosslinking of HmPVA–EPC in the water channels is believed to be responsible for the suppressed release. POLYM. ENG. SCI., 54:227–233, 2014. © 2013 Society of Plastics Engineers

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