This study attempted to determine the degree to which measures of health proneness and measures of negative affect represent two distinct, although related, constructs. In addition, it examined the relation between Antonovsky's salutogenic construct of sense of coherence (SOC) and Kobasa's health proneness construct of hardiness. Five health proneness and three negative affect measures were filled out by 164 male patients with coronary heart disease. The pattern of correlations between these measures and confirmatory factor analysis indicated that although the measures of health proneness are negatively related to measures of negative affect, these two sets of measures and the constructs to which they are related can be differentiated from each other. However, SOC was found to be less independent of negative affect than was hardiness.