We modelled the associations between the HEXACO dimensions of personality, Social Dominance Orientation (SDO), Right-Wing Authoritarianism (RWA) and prejudice towards dangerous, derogated and dissident groups (N = 454 undergraduates). Consistent with a Big-Five model, low Openness to Experience predicted RWA and therefore dangerous and dissident group prejudice. As predicted, low Emotionality (and Openness) rather than Agreeableness predicted SDO and therefore derogated and dissident group prejudice. Comparison with meta-analytic averages of Big-Five data supported expected similarities and differences in the association of Big-Five and HEXACO models of personality with ideology. Finally, Honesty-Humility simultaneously predicted increases in RWA but decreases in SDO, and thus opposing effects on prejudice. These opposing effects have gone unidentified in research employing Big-Five models of personality structure. Copyright © 2010 John Wiley & Sons, Ltd.