This study examines the relationships between intrinsic/extrinsic aspirations and subjective well-being (SWB; positive affect, negative affect, satisfaction with life) in a sample of 583 Spanish adults. Firstly, the results showed that high scores for SWB are related to high scores for intrinsic aspirations and, to a lesser extent, to low scores for extrinsic aspirations; it was also found that intrinsic aspirations are mainly related to positive indicators of well-being, whereas extrinsic aspirations are mainly associated with negative indicators. Secondly, the study also enabled exploration of the links between the domains of the Five-Factor Model and aspirations; thirdly, the results showed that intrinsic/extrinsic aspirations predict SWB beyond the Five Factors. The results demonstrate the importance of studying the content of human aspirations for understanding psychological health. Copyright © 2011 John Wiley & Sons, Ltd.