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Original Research Article
Effects of Caffeinated Versus Decaffeinated Energy Shots on Blood Pressure and Heart Rate in Healthy Young Volunteers
Article first published online: 30 MAY 2013
© 2013 Pharmacotherapy Publications, Inc.
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Volume 33, Issue 8, pages 779–786, August 2013
How to Cite
(Pharmacotherapy 2013;33(8):779–786) doi: 10.1002/phar.1296
This study was funded by a University of the Pacific Internal Seed Grant.
This study was presented as a poster at the American Heart Association's Cardiovascular Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2013 Scientific Sessions, New Orleans, Louisiana, March 19–22, 2013.
- Issue published online: 26 JUL 2013
- Article first published online: 30 MAY 2013
- energy drinks;
- 5-hour Energy shot;
- blood pressure;
- heart rate;
To evaluate the effects of a caffeinated 5-hour Energy shot compared with a decaffeinated 5-hour Energy shot as assessed by changes in blood pressure and heart rate in healthy, nonhypertensive volunteers.
Randomized, double-blind, controlled, crossover study.
Twenty healthy volunteers.
Subjects were randomized to receive either the caffeinated 5-hour Energy shot or the decaffeinated 5-hour Energy shot; after a washout period of at least 6 days, subjects were given the alternate energy shot.
Measurements and Main Results
Systolic (SBP) and diastolic (DBP) blood pressures were recorded for each subject at baseline and at 1, 3, and 5 hours after consumption of the energy shot. Heart rate, adverse effects, and energy levels were also assessed. Mean ± standard deviation (SD) baseline SBP for all study subjects was 114.06 ± 11.30 mm Hg and DBP was 69.53 ± 7.63 mm Hg. Mean changes in SBP between the caffeinated arm and the decaffeinated arm at the 1- and 3-hour time points were significantly increased compared with baseline (mean ± SD 6.08 ± 7.71 mm Hg at 1 hour [p=0.001] vs 3.33 ± 6.99 mm Hg at 3 hours [p=0.042]). Similarly, mean DBP changes between the caffeinated arm and the decaffeinated arm were significantly increased at the 1- and 3-hour time points compared with baseline (mean ± SD 5.18 ± 8.38 mm Hg at 1 hour [p=0.007] and 5.43 ± 7.21 mm Hg at 3 hours [p=0.005]). Heart rate, adverse effects, and energy levels were similar between the two groups.
Caffeinated energy shots significantly increased SBP and DBP over a 3-hour period compared with decaffeinated energy shots in healthy, nonhypertensive individuals.