Slow eroding biodegradable multiblock poloxamer copolymers

Authors

  • Jin Sun Ahn,

    1. Department of Chemistry, Division of Nano Sciences, Ewha Womans University, Daehyun-Dong, Seodaemun-Ku, Seoul, 120-750, Korea
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  • Ju Myung Suh,

    1. Department of Chemistry, Division of Nano Sciences, Ewha Womans University, Daehyun-Dong, Seodaemun-Ku, Seoul, 120-750, Korea
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  • Minyung Lee,

    1. Department of Chemistry, Division of Nano Sciences, Ewha Womans University, Daehyun-Dong, Seodaemun-Ku, Seoul, 120-750, Korea
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  • Byeongmoon Jeong

    Corresponding author
    1. Department of Chemistry, Division of Nano Sciences, Ewha Womans University, Daehyun-Dong, Seodaemun-Ku, Seoul, 120-750, Korea
    • Department of Chemistry, Division of Nano Sciences, Ewha Womans University, Daehyun-Dong, Seodaemun-Ku, Seoul 120-750, Korea
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Abstract

Biodegradable multiblock poloxamers (BMPs) with gel duration of 8 h to several weeks were prepared by varying their molecular weights from 4000 to 40 000 g mol−1. The molecular weight of the BMP was controlled by changing the poloxamer to coupling agent ratio. Assuming a micelle packing model of the BMP gel, as in the case of a poloxamer gel, the micelle properties and critical gel concentration of BMPs were investigated on the basis of the scaling concept. The findings suggest that the control of molecular weight by hydrolyzable groups can be a facile approach to optimize the gel properties for biomedical applications. Copyright © 2005 Society of Chemical Industry

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