This paper is based on a presentation given at the European Polymer Congress meeting held in Graz, Austria, 12-17 July 2009.
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On the hydrodynamic analysis of conformation in mixed biopolymer systems†
Article first published online: 15 OCT 2010
DOI: 10.1002/pi.2934
Copyright © 2010 Society of Chemical Industry
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How to Cite
Harding, S. E., Abdelhameed, A. S. and Morris, G. A. (2011), On the hydrodynamic analysis of conformation in mixed biopolymer systems. Polym. Int., 60: 2–8. doi: 10.1002/pi.2934
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Publication History
- Issue published online: 23 DEC 2010
- Article first published online: 15 OCT 2010
- Manuscript Accepted: 1 JUN 2010
- Manuscript Revised: 17 MAY 2010
- Manuscript Received: 17 FEB 2010
- Abstract
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Keywords:
- Haug triangle;
- conformation zoning;
- HYDFIT (combined global analysis);
- bead modelling
Abstract
A brief review is given of some of the advances in hydrodynamic methodologies for studying the conformation and flexibility of biomacromolecules in mixed systems. We consider first of all the evaluation of conformation type and flexibility in polymer systems with a quasi-continuous distribution of molecular weight, using polysaccharides and mucin glycoproteins as our main examples, and then conformation determination in discrete or paucidisperse systems such as aggregated antibody preparations. Copyright © 2010 Society of Chemical Industry