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Research Article

Strong resistance of poly (ethylene glycol) based L-tyrosine polyurethanes to protein adsorption and cell adhesion

  1. Jui-Chen Yang1,†,
  2. Chao Zhao1,†,
  3. I-Fan Hsieh2,
  4. Senthilram Subramanian1,
  5. Lingyun Liu1,
  6. Gang Cheng1,
  7. Lingyan Li1,
  8. Stephen Z. D. Cheng2,
  9. Jie Zheng1,*

Article first published online: 9 DEC 2011

DOI: 10.1002/pi.3220

Issue

Polymer International

Polymer International

Volume 61, Issue 4, pages 616–621, April 2012

Additional Information

How to Cite

Yang, J.-C., Zhao, C., Hsieh, I.-F., Subramanian, S., Liu, L., Cheng, G., Li, L., Cheng, S. Z. D. and Zheng, J. (2012), Strong resistance of poly (ethylene glycol) based L-tyrosine polyurethanes to protein adsorption and cell adhesion. Polym. Int., 61: 616–621. doi: 10.1002/pi.3220

Author Information

  1. 1

    Department of Chemical and Biomolecular Engineering, University of Akron, Akron, OH 44325, USA

  2. 2

    Department of Polymer Science, University of Akron, Akron, OH 44325, USA

  1. †

    These authors contributed equally to this work.

*Department of Chemical and Biomolecular Engineering, University of Akron, Akron, OH 44325, USA.

  1. †

    These authors contributed equally to this work.

Publication History

  1. Issue published online: 14 MAR 2012
  2. Article first published online: 9 DEC 2011
  3. Manuscript Accepted: 3 SEP 2011
  4. Manuscript Revised: 8 AUG 2011
  5. Manuscript Received: 16 MAY 2011

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Keywords:

  • antifouling;
  • polyurethane;
  • poly(ethylene glycol);
  • surface resistance

Abstract

Biofouling that involves protein adsorption, cell and bacteria adhesion, and biofilm formation between a surface and biological entities is a great challenge for biomedical and industry applications. In this work, L-tyrosine-derived polyurethanes (L-polyurethane) with different molecular weights of poly(ethylene glycol) (PEG) were synthesized, characterized and coated on gold surfaces using spin-coating. The non-fouling activity of different L-polyurethane films was evaluated by protein adsorption and cell adhesion. Surface plasmon resonance and cell assay results demonstrate that the PEG content in these L-polyurethanes contributes excellent resistance to protein adsorption and cell attachments. This work provides alternative and effective biomaterials for potential applications in blood-contacting devices. Copyright © 2011 Society of Chemical Industry

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