Get access

New degradable polyesters from deoxycholic acid and oligo(ethylene glycol)s

Authors

  • Magdalena C Stanciu,

    1. ‘Petru Poni’ Institute of Macromolecular Chemistry, Department of Natural Polymers, Bioactive and Biocompatible Materials, Iasi, Romania
    Search for more papers by this author
  • Marieta Nichifor

    Corresponding author
    • ‘Petru Poni’ Institute of Macromolecular Chemistry, Department of Natural Polymers, Bioactive and Biocompatible Materials, Iasi, Romania
    Search for more papers by this author

Correspondence to: Marieta Nichifor, ‘Petru Poni’ Institute of Macromolecular Chemistry, Department of Natural Polymers, Bioactive and Biocompatible Materials, Aleea Grigore Ghica Voda 41 A, 700457 Iasi, Romania. E-mail: nichifor@icmpp.ro

Abstract

A new class of polyesters was prepared by polycondensation of a bile acid, deoxycholic acid, and an oligo(ethylene glycol) (OEG) with molar mass ranging from 100 to 1500. The chemical structure and composition of the polyesters were confirmed by 1H-NMR, Fourier transform infrared spectroscopy and HPLC analysis. Polyester molar masses measured by gel permeation chromatography were between 5000 and 20 000. Thermal stability and glass transition temperature decreased with increasing length of OEG. Hydrolytic degradation was also enhanced by the presence of longer chain OEG. Polyesters obtained from OEG with molar mass ≥ 1000 were water soluble, semicrystalline and thermosensitive. As a function of the OEG length used for their preparation, the new polyesters can be useful for biomedical or industrial applications. © 2012 Society of Chemical Industry

Get access to the full text of this article

Ancillary