Development of new poly(ϵ-caprolactone)/chitosan films

Authors

  • Juliana V Azevedo,

    1. 3B's Research Group – Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Caldas das Taipas, Guimarães, Portugal
    2. ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal
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  • João F Mano,

    1. 3B's Research Group – Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Caldas das Taipas, Guimarães, Portugal
    2. ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal
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  • Natália M Alves

    Corresponding author
    1. ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal
    • 3B's Research Group – Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Caldas das Taipas, Guimarães, Portugal
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Correspondence to: Natália M Alves, 3B's Research Group – Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Department of Polymer Engineering, University of Minho, AvePark, Zona Industrial da Gandra, S. Cláudio de Barco 4806–909, Caldas das Taipas, Guimarães, Portugal. E-mail: nalves@dep.uminho.pt

Abstract

This study reports for the first time the production of poly(ϵ-caprolactone)/chitosan (PCL/CHT) films by solvent casting using a mixture of formic acid/acetone (70:30 vol%). Both uncrosslinked and crosslinked films with the natural crosslinker genipin were developed. The mechanical properties of the samples were analyzed by dynamical mechanical analysis (DMA) in the hydrated state. DMA was also successfully used for the first time to monitor in situ the crosslinking process as a function of time and crosslinker concentration. The compatibility between the polymers in the blended films was analyzed by Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC). It was found that phase distribution is highly dependent on the blend composition. The developed films could potentially be used in different applications, such as tissue engineering scaffolds. © 2013 Society of Chemical Industry

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