Non-catalyst synthesis and in vitro drug release property of poly(5,5-dimethyl-1,3-dioxan-2-one)-block-methoxy poly(ethylene glycol) copolymers

Authors

  • Yu Zhou,

    Corresponding author
    • Key Laboratory of Coal Conversion and New Carbon Material of Hubei Province, College of Chemical Engineering and Technology, Wuhan University of Science and Technology, Wuhan, People's Republic of China
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  • Niannian Cao,

    1. Key Laboratory of Coal Conversion and New Carbon Material of Hubei Province, College of Chemical Engineering and Technology, Wuhan University of Science and Technology, Wuhan, People's Republic of China
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  • Hongxiang Chen

    1. Key Laboratory of Coal Conversion and New Carbon Material of Hubei Province, College of Chemical Engineering and Technology, Wuhan University of Science and Technology, Wuhan, People's Republic of China
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Correspondence to: Yu Zhou, Key Laboratory of Coal Conversion and New Carbon Material of Hubei Province, College of Chemical Engineering and Technology, Wuhan University of Science and Technology, Wuhan 430081, People's Republic of China. E-mail: zhouy1015@163.com

Abstract

A series of poly(5,5-dimethyl-1,3-dioxan-2-one)-block-methoxy poly(ethylene glycol) (PDTC-b-mPEG) copolymers were synthesized by the ring-opening polymerization of 5,5-dimethyl-1,3-dioxan-2-one (DTC) in bulk, using methoxy poly(ethylene glycol) (mPEG) as initiator without adding any catalysts. The resulting copolymers were characterized by Fourier transform infrared spectra, 1H NMR and gel permeation chromatography. The influences of some factors such as the DTC/mPEG molar feed ratio, reaction time and reaction temperature on the copolymerization were investigated. The experimental results showed that mPEG could effectively initiate the ring-opening polymerization of DTC in the absence of catalyst, and that the copolymerization conditions had a significant effect on the molecular weight of PDTC-b-mPEG copolymer. In vitro drug release study demonstrated that the amount of indomethacin released from PDTC-b-mPEG copolymer decreased with increase in the DTC content in the copolymer. © 2013 Society of Chemical Industry

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