Rates of childhood obesity have more than tripled in the last 40 years, resulting in a challenge from the public sector and various governmental institutions for the development of effective prevention/early intervention programming. Based on an extensive review of the literature, an evidence-based, school-wide curriculum is proposed. Promoting Universal Longevity via School–family Ecologies (PULSE) is intended to change weight imbalance behaviors via proactive and long-term interventions directed toward all children and their families (universal prevention model) via the school setting. The authors provide a review of the literature and outline the conceptual model of PULSE. © 2009 Wiley Periodicals, Inc.