We examined the interrelationships among symptoms related to autism spectrum disorders (ASD) using a large representative sample and clinical groups of children aged 6 to 11 and youth aged 12 to 18 years rated by parents (N = 1,881) or teachers (N = 2,171). The samples included individuals from the United States and Canada from the standardization and validity studies for the Autism Spectrum Rating Scales. A three-factor solution comprising Social/Communication, Unusual Behaviors, and Self-Regulation provided the best fit to the data and was replicated across parent and teacher ratings. High coefficients of congruence across sexes, raters, ethnic groups, and age groups and for clinical groups were obtained. Implications for understanding the symptoms related to ASD and their use in practice are provided.