Short Communication

Proteomics analysis of human endothelial cell line EA.hy926 after exposure to GSM 900 radiation

  1. Reetta Nylund,
  2. Dariusz Leszczynski*

Article first published online: 30 MAR 2004

DOI: 10.1002/pmic.200300773

Issue

PROTEOMICS

PROTEOMICS

Special Issue: PROTEOMIC FORUM 2003 Proceedings of the International Meeting on Proteome Analysis, Munich, Germany 14-17 September 2003

Volume 4, Issue 5, pages 1359–1365, May 2004

Additional Information

How to Cite

Nylund, R. and Leszczynski, D. (2004), Proteomics analysis of human endothelial cell line EA.hy926 after exposure to GSM 900 radiation. PROTEOMICS, 4: 1359–1365. doi: 10.1002/pmic.200300773

Author Information

  1. BioNIR Research Group, STUK–Radiation and Nuclear Safely Authority, Helsinky, Finland

*STUK – Radiation and Nuclear Safety Authority, Laippatie 4 14, FIN-00880 Helsinki, Finland Fax: +358-9-75988464

Publication History

  1. Issue published online: 21 APR 2004
  2. Article first published online: 30 MAR 2004
  3. Manuscript Received: 6 OCT 2003

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Keywords:

  • Endothelium;
  • Human endothelial cell line;
  • Microwaves;
  • Mobile phone radiation

Abstract

The human endothelial cell line EA.hy926 was exposed to mobile phone radiation and the effect on protein expression was examined using two-dimensional electrophoresis (2-DE). Up to 38 various proteins have statistically significantly altered their expression levels following the irradiation. Four proteins were identified with matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS). Two of the affected proteins were determined to be isoforms of cytoskeletal vimentin. This finding supports our earlier presented working hypothesis which indicated that the mobile phone radiation might affect the cytoskeleton and might have an effect on the physiological functions that are regulated by the cytoskeleton.

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