Is the intrinsic disorder of proteins the cause of the scale-free architecture of protein–protein interaction networks?
Article first published online: 6 FEB 2007
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Special Issue: SYSTEMS BIOLOGY
Volume 7, Issue 6, pages 961–964, No. 6 March 2007
How to Cite
Schnell, S., Fortunato, S. and Roy, S. (2007), Is the intrinsic disorder of proteins the cause of the scale-free architecture of protein–protein interaction networks?. Proteomics, 7: 961–964. doi: 10.1002/pmic.200600455
- Issue published online: 16 MAR 2007
- Article first published online: 6 FEB 2007
- Manuscript Received: 21 JUN 2006
- Division of Information and Intelligent Systems, National Science Foundation. Grant Number: 0513650
- Volkswagen Foundation
- Network topology;
- Protein disorder;
- Protein–protein interaction networks
In protein–protein interaction (PPI) networks certain topological properties appear to be recurrent: network maps are considered scale-free. It is possible that this topology is reflected in the protein structure. In this paper, we investigate the role of protein disorder in the network topology. We find that the disorder of a protein (or of its neighbors) is independent of its number of PPIs. This result suggests that protein disorder does not play a role in the scale-free architecture of protein networks.