Is a gene-centric human proteome project the best way for proteomics to serve biology?


  • Thierry Rabilloud,

    Corresponding author
    1. Biochemistry and Biophysics of Integrated Systems, UMR CNRS-CEA-UJF 5092, CEA Grenoble, iRTSV/BSBBSI, Grenoble, France
    • iRTSV/BBSI, CEA-Grenoble, 17 rue des martyrs, F-38054 GRENOBLE CEDEX 9, France Fax: +33-4-38-78-44-99
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  • Denis Hochstrasser,

    1. Department of Genetic and Laboratory Medicine, Laboratory Medicine Division, Geneva University, Geneva University Hospital and Swiss Centre of Applied Human Toxicology, Geneva, Switzerland
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  • Richard J. Simpson

    1. Ludwig Institute for Cancer Research Inc, Royal Melbourne Hospital, Parkville, Australia
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With the recent developments in proteomic technologies, a complete human proteome project (HPP) appears feasible for the first time. However, there is still debate as to how it should be designed and what it should encompass. In “proteomics speak”, the debate revolves around the central question as to whether a gene-centric or a protein-centric proteomics approach is the most appropriate way forward. In this paper, we try to shed light on what these definitions mean, how large-scale proteomics such as a HPP can insert into the larger omics chorus, and what we can reasonably expect from a HPP in the way it has been proposed so far.