Is a gene-centric human proteome project the best way for proteomics to serve biology?
Article first published online: 19 JUL 2010
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 10, Issue 17, pages 3067–3072, No. 17 September 2010
How to Cite
Rabilloud, T., Hochstrasser, D. and Simpson, R. J. (2010), Is a gene-centric human proteome project the best way for proteomics to serve biology?. Proteomics, 10: 3067–3072. doi: 10.1002/pmic.201000220
- Issue published online: 25 AUG 2010
- Article first published online: 19 JUL 2010
- Manuscript Accepted: 8 JUN 2010
- Manuscript Revised: 4 JUN 2010
- Manuscript Received: 3 APR 2010
- Human proteome project;
- Multiple reaction monitoring;
- Systems biology
With the recent developments in proteomic technologies, a complete human proteome project (HPP) appears feasible for the first time. However, there is still debate as to how it should be designed and what it should encompass. In “proteomics speak”, the debate revolves around the central question as to whether a gene-centric or a protein-centric proteomics approach is the most appropriate way forward. In this paper, we try to shed light on what these definitions mean, how large-scale proteomics such as a HPP can insert into the larger omics chorus, and what we can reasonably expect from a HPP in the way it has been proposed so far.