SEARCH

SEARCH BY CITATION

Keywords:

  • Apoptosis;
  • Cell biology;
  • Genetic disease;
  • Mitochondria;
  • Neurodegenerative disease;
  • Oxidative stress

Abstract

This review compiles results of medical relevance from mitochondrial proteomics, grouped either according to the type of disease – genetic or degenerative – or to the involved mechanism – oxidative stress or apoptosis. The findings are commented in the light of our current understanding of uniformity/variability in cell responses to different stimuli. Specificities in the conceptual and technical approaches to human mitochondrial proteomics are also outlined.