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Dissecting cell death with proteomic scalpels

Authors

  • Li-Shun Wang,

    1. Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai, P. R. China
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  • Li Xia,

    1. Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai, P. R. China
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  • Shao-Min Shen,

    1. Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Institute of Health Science, Shanghai Institutes for Biological Sciences (SIBS), Shanghai, P. R. China
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  • Ying Zheng,

    1. Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai, P. R. China
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  • Yun Yu,

    1. Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai, P. R. China
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  • Guo-Qiang Chen

    1. Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai, P. R. China
    2. Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Institute of Health Science, Shanghai Institutes for Biological Sciences (SIBS), Shanghai, P. R. China
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Abstract

Programmed cell deaths (PCD), including apoptosis, autophagy and programmed necrosis, are genetically determined, complex processes in multi-cellular organisms. Problems with the regulation of PCD have been implicated in a number of diseases including myocardial infarction, cancer and autoimmune disease. As a result, the investigation on PCD regulation has stirred considerable interest. In the past decades, many PCD-involved proteins had been identified as being modulated by post-translational mechanisms, including post-translational modification, protein-protein interactions and protein cleavage, which fall precisely within the range of proteomic analysis. Contemporary quantitative proteomics, interactomics, PTMomics, degradomics, chemical proteomics and pharmacoproteomics have been quickly applied in the field of PCD research, and possess the potential to be the driving forces of the field. This review attempts to highlight some of the major achievements in the application of proteomics in PCD research to trigger further thinking and application.

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