Get access

Post-genomics of bone metabolic dysfunctions and neoplasias

Authors

  • Giulia Bernardini,

    1. Università degli Studi di Siena, Dipartimento di Biotecnologie, Siena, Italy
    Search for more papers by this author
  • Daniela Braconi,

    1. Università degli Studi di Siena, Dipartimento di Biotecnologie, Siena, Italy
    Search for more papers by this author
  • Adriano Spreafico,

    1. Università degli Studi di Siena, Centro Interdipartimentale per lo Studio Biochimico delle Patologie Osteoarticolari, Siena, Italy
    Search for more papers by this author
  • Annalisa Santucci

    Corresponding author
    1. Università degli Studi di Siena, Dipartimento di Biotecnologie, Siena, Italy
    2. Università degli Studi di Siena, Centro Interdipartimentale per lo Studio Biochimico delle Patologie Osteoarticolari, Siena, Italy
    • Università degli Studi di Siena, Dipartimento di Biotecnologie, via Fiorentina 1, 53100 Siena, Italy, Fax: +39-0577234903
    Search for more papers by this author

Abstract

Post-genomic research on osteoblastic and osteoclastic cells, in contrast to that on many other cell types, has only been undertaken recently. Nevertheless, important information has been gained from these investigations on the mechanisms involved in osteoblast differentiation and on markers relevant for tissue regeneration and therapeutic validation of drugs, hormones and growth factors. These protein indicators may also have a diagnostic and prognostic value for bone dysfunctions and tumors. Some reviews have already focused on the application of transcriptomics and/or proteomics for exploring skeletal biology and related disorders. The main goal of the present review is to systematically summarize the most relevant post-genomic studies on various metabolic bone diseases (osteoporosis, Paget's disease and osteonecrosis), neoplasias (osteosarcoma) and metabolic conditions that indirectly affect bone tissue, such as alkaptonuria.

Get access to the full text of this article

Ancillary