Review

Polymeric monolithic materials modified with nanoparticles for separation and detection of biomolecules: A review

  1. Damian Connolly1,†,
  2. Sinead Currivan1,
  3. Brett Paull2,†,*

Article first published online: 29 AUG 2012

DOI: 10.1002/pmic.201200142

Issue

PROTEOMICS

PROTEOMICS

Special Issue: Focus on Emerging Gel-Free Separation and Detection Methods

Volume 12, Issue 19-20, pages 2904–2917, October 2012

Additional Information

How to Cite

Connolly, D., Currivan, S. and Paull, B. (2012), Polymeric monolithic materials modified with nanoparticles for separation and detection of biomolecules: A review. Proteomics, 12: 2904–2917. doi: 10.1002/pmic.201200142

Author Information

  1. 1

    Irish Separation Science Cluster (ISSC), School of Chemical Sciences, Dublin City University, Ireland

  2. 2

    Australian Centre for Research on Separation Science (ACROSS), School of Chemistry, University of Tasmania, Hobart, Tasmania, Australia

  1. †

    These authors contributed equally to this review.

* Correspondence: Professor Brett Paull, Australian Centre for Research on Separation Science (ACROSS), School of Chemistry, University of Tasmania, Hobart 7001, Tasmania, Australia
E-mail: brett.paull@utas.edu.au; damian.connolly@dcu.ie

  1. †

    These authors contributed equally to this review.

Publication History

  1. Issue published online: 19 OCT 2012
  2. Article first published online: 29 AUG 2012
  3. Accepted manuscript online: 7 AUG 2012 08:44AM EST
  4. Manuscript Accepted: 10 MAY 2012
  5. Manuscript Revised: 1 MAY 2012
  6. Manuscript Received: 4 APR 2012

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Keywords:

  • Biomolecules;
  • Detection;
  • Nanoparticles;
  • Polymer monoliths;
  • Separation;
  • Technology

Polymer monolithic materials have found particularly utility in the field of bioanalysis, particularly in the area of separation science, for both enrichment and trapping of biomolecules and their analytical/preparative separations. Nanoparticle-modified monoliths have recently emerged as a new class of substrate, with unique characteristics and structure, and with selectively tailored surface chemistries for target molecules. Although several reviews exist on the applications of nanoparticles in analytical science, this review is the first to specifically summarise the applications in bioanalysis of nanoparticle-modified polymer monolithic materials. The review covers the range of nanoparticles being utilised in this way, their specific applications and future trends.

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