Polymeric monolithic materials modified with nanoparticles for separation and detection of biomolecules: A review

Authors

  • Damian Connolly,

    1. Irish Separation Science Cluster (ISSC), School of Chemical Sciences, Dublin City University, Ireland
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    • These authors contributed equally to this review.

  • Sinead Currivan,

    1. Irish Separation Science Cluster (ISSC), School of Chemical Sciences, Dublin City University, Ireland
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  • Brett Paull

    Corresponding author
    • Australian Centre for Research on Separation Science (ACROSS), School of Chemistry, University of Tasmania, Hobart, Tasmania, Australia
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    • These authors contributed equally to this review.


Correspondence: Professor Brett Paull, Australian Centre for Research on Separation Science (ACROSS), School of Chemistry, University of Tasmania, Hobart 7001, Tasmania, Australia

E-mail: brett.paull@utas.edu.au; damian.connolly@dcu.ie

Abstract

Polymer monolithic materials have found particularly utility in the field of bioanalysis, particularly in the area of separation science, for both enrichment and trapping of biomolecules and their analytical/preparative separations. Nanoparticle-modified monoliths have recently emerged as a new class of substrate, with unique characteristics and structure, and with selectively tailored surface chemistries for target molecules. Although several reviews exist on the applications of nanoparticles in analytical science, this review is the first to specifically summarise the applications in bioanalysis of nanoparticle-modified polymer monolithic materials. The review covers the range of nanoparticles being utilised in this way, their specific applications and future trends.

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