Research Article

Increased anaerobic metabolism is a distinctive signature in a colorectal cancer cellular model of resistance to antiepidermal growth factor receptor antibody

  1. Francesca Monteleone1,†,
  2. Roberta Rosa2,†,
  3. Monica Vitale1,3,†,
  4. Chiara D'Ambrosio4,
  5. Mariangela Succoio1,3,
  6. Luigi Formisano2,
  7. Lucia Nappi2,
  8. Maria Fiammetta Romano3,
  9. Andrea Scaloni4,
  10. Giampaolo Tortora5,‡,
  11. Roberto Bianco2,‡,
  12. Nicola Zambrano1,3,*

Article first published online: 24 JAN 2013

DOI: 10.1002/pmic.201200303

Issue

PROTEOMICS

PROTEOMICS

Volume 13, Issue 5, pages 866–877, March 2013

Additional Information

How to Cite

Monteleone, F., Rosa, R., Vitale, M., D'Ambrosio, C., Succoio, M., Formisano, L., Nappi, L., Romano, M. F., Scaloni, A., Tortora, G., Bianco, R. and Zambrano, N. (2013), Increased anaerobic metabolism is a distinctive signature in a colorectal cancer cellular model of resistance to antiepidermal growth factor receptor antibody. Proteomics, 13: 866–877. doi: 10.1002/pmic.201200303

Author Information

  1. 1

    CEINGE Biotecnologie Avanzate, Napoli, Italy

  2. 2

    Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Napoli, Italy

  3. 3

    Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, Napoli, Italy

  4. 4

    Proteomics and Mass Spectrometry Laboratory, ISPAAM, National Research Council, Napoli, Italy

  5. 5

    Oncologia Medica, Dipartimento di Medicina, Università di Verona, Policlinico Borgo Roma, Verona, Italy

  1. †

    These authors contributed equally to this study.

  2. ‡

    Additional corresponding authors: Professor Giampaolo Tortora, E-mail: giampaolo.tortora@univr.it, and Professor Roberto Bianco, E-mail: robianco@unina.it

* Correspondence: Professor Nicola Zambrano, CEINGE Biotecnologie Avanzate and Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Via G. Salvatore 486, 80145 Napoli, Italy
E-mail: zambrano@unina.it
Fax: +39 081 3737 808

  1. †

    These authors contributed equally to this study.

  2. ‡

    Additional corresponding authors: Professor Giampaolo Tortora, E-mail: giampaolo.tortora@univr.it, and Professor Roberto Bianco, E-mail: robianco@unina.it

  3. Colour Online: See the article online to view Fig. 1 in colour.

Publication History

  1. Issue published online: 8 MAR 2013
  2. Article first published online: 24 JAN 2013
  3. Accepted manuscript online: 26 DEC 2012 08:46AM EST
  4. Manuscript Accepted: 14 NOV 2012
  5. Manuscript Revised: 12 OCT 2012
  6. Manuscript Received: 20 JUL 2012

Funded by

  • Ministero dell'Università e della Ricerca Scientifica (MIUR)
  • Associazione Italiana per la Ricerca sul Cancro (AIRC). Grant Numbers: PS 126-Ind, 2011–2014, MFAG-11473, MIUR_PRIN2008_CCPKRP_002, MIUR_FIRB2008_RBNE08YFN3_003
  • Finanziamenti per l'Avvio di Ricerche Originali (FARO). Grant Numbers: AIRC_IG-11930, MIUR_PRIN 2009×23L78_005

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (837K)

As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.

FilenameFormatSizeDescription
pmic7328-sup-0001-TableS1.docx40KSupplementary Table 1. The Sequences and charge state of each peptide used for identification of the proteins by MALDI-TOF PMF and nanoLC-ESI-LIT-MS/MS experiments.

Please note: Wiley-Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

View Full Article with Supporting Information (HTML) Get PDF (837K)