Current address: Dr. Peter P. Liu, Ottawa Heart Institute, Ottawa, ON, Canada.
The cardiovascular exosome: Current perspectives and potential
Article first published online: 20 APR 2013
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Special Issue: Focus on Analysis of Extracellular Vesicles
Volume 13, Issue 10-11, pages 1654–1659, May 2013
How to Cite
Cosme, J., Liu, P. P. and Gramolini, A. O. (2013), The cardiovascular exosome: Current perspectives and potential. Proteomics, 13: 1654–1659. doi: 10.1002/pmic.201200441
Colour Online: See the article online to view Fig. 1 in colour.
- Issue published online: 3 JUN 2013
- Article first published online: 20 APR 2013
- Accepted manuscript online: 25 MAR 2013 03:20AM EST
- Manuscript Accepted: 18 FEB 2013
- Manuscript Revised: 25 JAN 2013
- Manuscript Received: 24 SEP 2012
- Heart and Stroke Foundation of Ontario
- Canadian Institutes of Health Research
- Intercellular communication;
- Systems biology
The exosome is a secreted microvesicle that has been shown to contain genetic material and proteins and is involved in multiple levels of cellular communication. The cardiovascular exosome proteome is a promising subproteome that warrants investigation since a detailed understanding of its role in the heart should improve our comprehension of intercellular communication in the heart, and may even assist in biomarker discovery. Indeed, uncovering the role of the exosome in cardiovascular physiology could be accomplished with the application of scientific approaches and insights gained from studies of exosomes in other fields, such as cancer biology and immunology, where much of the established knowledge of the exosome has been generated. In the present review, we discuss the relevant literature and examine areas of investigation that would bring the cardiovascular exosome to the forefront of intercellular communication in the heart.