These authors have contributed equally to this work.
Nitric oxide-cold stress signalling cross-talk, evolution of a novel regulatory mechanism
Article first published online: 17 MAY 2013
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 13, Issue 12-13, pages 1816–1835, June 2013
How to Cite
Sehrawat, A., Gupta, R. and Deswal, R. (2013), Nitric oxide-cold stress signalling cross-talk, evolution of a novel regulatory mechanism. Proteomics, 13: 1816–1835. doi: 10.1002/pmic.201200445
Colour Online: See the article online to view Figs. 1–4 in colour.
- Issue published online: 5 JUL 2013
- Article first published online: 17 MAY 2013
- Accepted manuscript online: 12 APR 2013 04:01AM EST
- Manuscript Accepted: 31 JAN 2013
- Manuscript Revised: 15 JAN 2013
- Manuscript Received: 28 SEP 2012
- Special Assistant Programme. Grant Number: 3–10/2011
- Department of Botany, a research grant provided by University of Delhi and DBT. Grant Number: BT/PR10799/NDB/51/171/2008
- Department of Biotechnology, Government of India
- Cold stress responsive proteins;
- Plant proteomics;
Plants enhance their cold stress tolerance by cold acclimation, a process which results in vast reprogramming of transcriptome, proteome and metabolome. Evidence suggests nitric oxide (NO) production during cold stress which regulates genes (especially the C-repeat binding factor (CBF) cold stress signalling pathway), diverse proteins including transcription factors (TFs) and phosphosphingolipids. About 59% (redox), 50% (defence/stress) and 30% (signalling) cold responsive proteins are modulated by NO-based post translational modifications (PTMs) namely S-nitrosylation, tyrosine nitration and S-glutathionylation, suggesting a cross-talk between NO and cold. Analysis of cold stress responsive deep proteome in apoplast, mitochondria, chloroplast and nucleus suggested continuation of this cross-talk in sub-cellular systems. Modulation of cold responsive proteins by these PTMs right from cytoskeletal elements in plasma membrane to TFs in nucleus suggests a novel regulation of cold stress signalling. NO-mediated altered protein transport in nucleus seems an important stress regulatory mechanism. This review addresses the NO and cold stress signalling cross-talk to present the overview of this novel regulatory mechanism.